Tuesday, August 28, 2012

APOPTOSIS (Programmed Cell Death)

APOPTOSIS (Programmed Cell Death) ~ Apoptosis versus Necrosis • APOPTOSIS (eg. following DNA damage, hypoxia) • Prevents inflammatory response: – Characteristic morphological changes: – Membrane blebbing, cell shrinkage, chromatin condensation, DNA cleavage, fragmentation of cell into apoptotic bodies – Rapid engulfment of apoptotic cells/bodies by Macrophages or neighbouring cells • NECROSIS (occurs following acute trauma or post-apoptosis) • Promotes inflammatory response: – Cell and its organelles swell, rupture and release cellular contents ....

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